Little Evidence That Diet, Lifestyle Cuts Alzheimer's Risk

Numerous studies have attempted to link specific behaviors and health conditions to the onset of Alzheimer's disease, but scientists still can't say for sure that anything you do or don't do will prevent the brain disorder, according to a new U.S. review of recent research. The U.S. National Institutes of Health convened a conference last spring to analyze 18 studies of potential risk factors, such as poor eating habits, chronic illness, smoking or little exercise, and development of Alzheimer's disease. "Although we are not dismissing the potential or important role that these major risk factors might play in the development of Alzheimer's disease, at this time, with what we have currently, we cannot confirm any risk associations," said study lead author Dr. Martha L. Daviglus, a professor of preventive medicine and medicine at the Northwestern University Feinberg School of Medicine in Chicago.

"So we need to conduct more research, if we want to have the evidence in hand," she added. The study, which summarizes the NIH conference results, is published in the May 9 online edition and September print issue of the Archives of Neurology. For now, older age is the leading known risk factor for Alzheimer's disease, the study noted. A gene variation is also tied to increased risk, it said. An estimated 5.3 million Americans struggle with Alzheimer's, a figure projected to grow as the country's Baby Boomer population ages, the authors said. The disease is responsible for between 60 and 80 percent of dementia cases. "What we're talking about here is something that is going to affect so many Americans in the years to come," said one expert, Catherine Roe, an instructor in neurology at Washington University School of Medicine in St. Louis. "In fact, there's going to be an explosion in the next 50 years, because everyone is living longer in general," she said.

The studies included in the NIH research review were conducted between 1984 and 2009 in English. Participants were at least 50 years old and living in developed countries. Some of the studies looked into dietary influences, such as folic acid intake, Mediterranean diet and nutritional supplements. Others looked for a link between health problems, such as diabetes or high cholesterol, and Alzheimer's. Still others explored levels of physical activity or alcohol consumption and risk of Alzheimer's disease. The NIH team found that, as a whole, the studies were "compromised by methodological limitations" that undercut the ability to draw a firm association between any particular behavioral habit and/or health condition and Alzheimer's.

You have read this article Alzheimer disease / Alzheimer's Risk / Brain / cholesterol / Gene / health care / Smoking with the title Alzheimer disease. You can bookmark this page URL http://aganaktismenoi-volos.blogspot.com/2011/05/little-evidence-that-diet-lifestyle.html. Thanks!

High Cholesterol in Middle Age May Not Raise Dementia Risk for Women

For years, doctors have been saying that keeping your cholesterol levels in check as you age is good for your brain as well as your heart, but a new study suggests the connection between cholesterol and dementia later in life isn't quite so clear-cut. After more than 1,400 Swedish women followed for 32 years, Johns Hopkins researchers found that those with high cholesterol at mid-life were at no greater risk of developing Alzheimer's and other types of dementia than women with lower levels. In addition, the women whose cholesterol levels decreased the most from middle to older age were 2.5 times more likely to develop dementia than those whose levels increased or stayed the same.

Both cell and animal studies have suggested that high cholesterol contributes to Alzheimer's disease, the researchers noted, but they stressed that the relationship between cholesterol and dementia may vary over a lifetime. "Our findings highlight how risk factors can change over the course of a person's life span," said Michelle M. Mielke, an assistant professor of psychiatry at Hopkins and lead author of the study, which was published online Nov. 10 in the journal Neurology. "My biggest worry is that people will look at these results and decide that cholesterol doesn't matter, but that's not what we're saying," Mielke added.

"We know that high cholesterol is a very strong risk factor for cardiovascular disease and still needs to be treated with diet, exercise and possibly medication." Mielke added that it was unclear why a decline in cholesterol levels in old age was linked to a higher risk of dementia, but said it might be an early part of the disease process. "As people start to develop symptoms, they often forget to eat and start losing weight, and that may be why their cholesterol goes down." For the study, Mielke and her colleagues examined data from the Prospective Population Study of Women, which began in 1968 and consisted of 1,462 Swedish women between the ages of 38 and 60.

You have read this article Alzheimer disease / Brain / cholesterol / dementia / heart / women with the title Alzheimer disease. You can bookmark this page URL http://aganaktismenoi-volos.blogspot.com/2010/11/high-cholesterol-in-middle-age-may-not.html. Thanks!