Do Immune System Ills Help Drive Type 2 Diabetes?

New research suggests that the development of insulin resistance and type 2 diabetes may be linked to an immune system reaction gone awry. "The main point of this study is trying to shift the emphasis in thinking of type 2 diabetes as a purely metabolic disease, and instead emphasize the role of the immune system in type 2," said study co-author Dr. Daniel Winer, an endocrine pathologist at Toronto General Hospital in Canada. When the research began, Winer was a postdoctoral fellow at Stanford University in California. The researchers have identified immune system antibodies in people who are obese and insulin-resistant that aren't present in people who are obese without insulin resistance. They also tested a drug that modifies the immune system in mice fed a fatty diet, and found that the medication could help maintain normal blood sugar levels.

The findings were published online April 17 in the journal Nature Medicine. Funding for the study was provided by the U.S. National Institutes of Health. Nearly 26 million Americans have diabetes, according to the U.S. Centers for Disease Control and Prevention. Between 90 percent and 95 percent of these cases are type 2 diabetes, where the body doesn't use insulin efficiently, so the pancreas must make increasing amounts of insulin. Eventually, the pancreas stops making enough insulin to meet the increased demand. The less common form of the disease, type 1 diabetes, occurs when the immune system mistakenly destroys the insulin-producing beta cells in the pancreas. This type of diabetes is considered an autoimmune disease, and isn't linked to how much a person weighs.

Although the causes of type 2 haven't been clear, it's known that the disease runs in families, suggesting a genetic component. Also, while type 2 is strongly linked to increased weight, not everyone who is overweight gets type 2 diabetes. And, that's what got the researchers searching for another factor. Winer explained that excess weight has been linked to inflammation, which can cause the immune system to react. As visceral fat (abdominal fat) expands, it eventually runs out of room, explained Winer. At that point, the fat cells may become stressed and inflamed, and eventually the cells die. When that happens, immune system cells known as macrophages come to sweep up the mess.

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Trans Fats While Breast-Feeding May Plump Up Baby

Breast-fed babies are much more likely to put on excess body fat if their mother's diet is high in trans fats, finds a new study. U.S. researchers looked at 96 women and their babies. Infants whose mothers consumed more than 4.5 grams of trans fats per day while breast-feeding were twice as likely to have a high percentage of body fat than babies whose mothers consumed lower amounts of trans fats. The study also found that mothers who consumed more than 4.5 grams a day of trans fats had a nearly six times greater risk of excessive fat accumulation. This suggests that intake of trans fats could have a more significant weight gain effect on women when they're breast-feeding than at other times in their lives, said the University of Georgia researchers.

The findings were recently published online in the European Journal of Clinical Nutrition. Further research is needed to learn more about how a mother's consumption of trans fats may affect her child's long-term health. "It would help to be able to follow the child from when the mother was pregnant, through birth, and then adolescence, so that we can confirm what the type of infant feeding and maternal diet during breast-feeding have to do with the recent epidemic of childhood obesity," study co-author Alex Anderson, an assistant professor in the UGA College of Family and Consumer Sciences, said in a university news release.

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Sleep-Deprived Teens Eat More Fat, Study Finds

Teens who sleep less than eight hours a night are more likely to eat a high-fat diet that puts them at risk for obesity and the many health problems connected with it, new research shows. The study, published in the Sept. 1 issue of the journal Sleep, found that these sleep-deprived teens consumed 2.2 percent more calories from fat, and ate more snacks than those who slept eight hours or more a night. They also ate more total calories. "There's been a lot of research over the last five years implicating insufficient sleep with obesity," said study author Dr. Susan Redline, of Brigham and Women's Hospital and Beth Israel Deaconess Medical Center in Boston.

"Some experimental studies on sleep deprivation in controlled laboratory environments show a craving for fatty foods among the participants" who got less sleep, she said. Redline, a professor of medicine with the school's division of sleep medicine, said sleep-deprived teens may suffer from metabolic disturbances that have been linked to obesity and insulin resistance in other research with shift workers whose sleep was also irregular. Metabolism is the body's process for turning calories into energy. Lack of sleep can affect metabolism by changing the level of appetite-regulating hormones like leptin and ghrelin, setting the stage for poor eating habits, Redline explained.

In addition to being a possible cause of metabolic problems, fewer hours of sleep provided teens with "more opportunities to eat," Redline said. Teens need about nine hours of sleep every night to feel rested and alert the next day, but few teens get that amount, experts said. "I almost never see anyone who is sleeping more than seven hours a night," said Dr. Paula Elbirt, an associate professor of pediatrics and adolescent medicine at Mount Sinai Medical Center in New York City. Insufficient sleep among teens is "the rule, not the exception," she said. Elbirt said the "adolescent lifestyle" encourages teens to stay up late.

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Short-Term Overeating Could Make Long-Term Weight Loss Tougher

If you think a few weeks of slothful behavior and caloric overindulgence can be easily worked off at the gym, think again. New Swedish research suggests that just a month's worth of unhealthy living changes physiology, making piled-on fat even harder to lose. "A short period of [over-eating] can have later long-term effects," said study co-author Dr. Torbjorn Lindstrom, an associate professor in the department of medical and health sciences within the faculty of health sciences at Linkoping University. "Based on this, it can be recommended to avoid very high food-intake that might occur during shorter periods in normal life."

Lindstrom and his colleagues report their findings in the current issue of Nutrition & Metabolism. They focused on 18 normal-weight healthy participants, averaging 26 years of age. For one month, all 18 were placed on a restricted physical activity regimen that involved the equivalent of no more than 5,000 steps per day. Five thousand steps, the team noted, is the threshold for a "sedentary" lifestyle, whereas a "physically active" lifestyle involved 10,000 steps or more. In addition, participants embarked on diets involving a 70 percent jump in daily caloric intake mainly from fast food amounting to about 5,750 calories ingested per day. The research also included a comparison group who did not change their diet/activity.

By the end of the month, the feasting group gained an average of 14 pounds. Their fat mass, specifically, was found to have gone up from about 20 percent of total body weight, to nearly 24 percent after the month-long intervention. Participants lost most of that new weight over the ensuing six months. However, one year after the study's end, participants still registered a noticeable gain in fat mass compared with their pre-study status. This fat stuck around despite the fact that the participants had returned to their lower-calorie pre-study diet and more active routines. Two-and-a-half years after the study, fat mass gains were even greater, registering just under 7 pounds on average, the researchers found. There was no such long-term change among the control group who had stuck to their usual diet.

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