Can Hormone Therapy or the Pill Prevent Brain Aneurysms?

Taking birth control pills or hormone replacement therapy could protect women against brain aneurysms later in life, a new study suggests, although one neurologist questioned the quality of the research. Cerebral aneurysms occur when a blood vessel in the brain weakens and balloons out, potentially leading to a hemorrhagic (or bleeding) stroke if the vessel bursts. These types of aneurysms are more common in women than men, possibly because lower levels of female hormones after menopause play a role in their development, the study authors noted.

Brain aneurysms are more common after the age of 40 and are most likely to burst when people are in their 50s. In the study, Dr. Michael Chen, of Rush University Medical Center, and colleagues interviewed 60 women who had experienced brain aneurysms and asked about their use of birth control pills and hormone replacement therapy, and compared their answers to those from a group of almost 4,700 other women in the general U.S. public. The women who had brain aneurysms were significantly less likely to have taken birth control pills or received hormone replacement therapy, and were also more likely to have entered menopause earlier, according to the report published online May 4 in the Journal of NeuroInterventional Surgery.

Previous research has suggested that taking birth control pills lowers the risk of hemorrhagic (bleeding) stroke in later life. However, women who either begin menstruating at an early age, don't have children, or both, face a higher risk. Because estrogen is important for the repair and maintenance of blood vessel walls, a drop in the levels of the female hormone is believed to be the reason for the increased risk to the structure of these vessels, the study authors noted in background information about the research. However, commenting on the study, neurologist Dr. Cathy Sila said the research is flawed and its conclusions overstated.

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New Clues to How Gastric Bypass Surgery Combats Diabetes

Gastric bypass surgery has been known to improve blood sugar control, often sending people with type 2 diabetes into remission, but experts have long wondered exactly how that happens. Now, a new study provides some clues. Circulating amino acids linked with insulin resistance decline dramatically in those who have the bypass surgery, the researchers discovered. They compared 10 obese people with diabetes who had the surgery with 11 who lost weight through dieting. "Something happens after gastric bypass that does not happen as much after the diet-induced weight loss," said Dr. Blandine Laferrere, an associate professor of medicine at St. Luke's Roosevelt Hospital Center and Columbia University, both in New York City.

The surgery, which reduces the stomach to the size of a small pouch, also modifies the junction between the stomach and small intestine. It leads to a dramatic reduction in the level of circulating amino acids that have been linked with diabetes. "The fact that gastric bypass results in the remission of diabetes in the majority of patients is not new," said Laferrere. According to background information in the study, 50 percent to 80 percent of diabetes cases go into remission after the surgery. What doctors have been trying to figure out, she said, is why the bypass surgery is so good at making the diabetes disappear. "The diabetes improves almost immediately, before a significant amount of weight loss occurs," she said. "That points out it is something other than the weight loss."

In the new study, the researchers evaluated biochemical compounds involved in metabolic reactions in the participants. Each group had lost about 20 pounds. The investigators found that the bypass patients had much lower levels of amino acids known as branched-chain amino acids, and the amino acids phenylalanine and tyrosine. "Those changes in the amino acids could be implicated in the mechanism of diabetes remission after gastric bypass," Laferrere said. Experts know the amino acids are linked with insulin resistance partly due to animal studies, she said. "If you supplement the diet of rats with branched-chain amino acids, you can induce more insulin resistance," she explained.

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Gene Therapy Against HIV Not a Proven Cure

Experts are reacting with cautious optimism to the announcement Monday that researchers reconfigured immune cells so that they became resistant to HIV in six patients infected with the virus. But they say the jury is out on whether the technique might ever spell an end to AIDS. The goal is ultimately a cure or what's called a "functional cure" having the body permanently keep HIV at bay but "we're not there yet," stressed Dr. Michael Kolber, professor of medicine and director of the Comprehensive AIDS Program at the University of Miami Miller School of Medicine.

The trial, reported Feb. 28 at a meeting of HIV specialists in Boston, "was a proof-of-principle that they could go in and do this. They demonstrated that the cells stayed in the patients, but the patients were not cured," said Kolber, who was not involved in the new research. Another expert agreed that the treatment's true potential remains uncertain. "If successful, this probably could have wide application, but going from six patients to an entire epidemic is a ways to go," said Dr. Michael Horberg, director of HIV/AIDS at Kaiser Permanente Health Plan and vice chair of the HIV Medicine Association.

"With other successes we've already had, that makes it more promising and people are starting to have a greater vision as to what's possible." However, as Kolber pointed out, this trial was what's known as a phase I trial, which means it was primarily looking at safety, not effectiveness, although investigators do often report on initial effectiveness results at this stage. The idea came from an isolated case that first made headlines in 2009, involving the so-called "Berlin patient." This man, an American AIDS patient living in Germany, was apparently cured after receiving blood cells from a donor who happened to have a rare, natural immunity to HIV.

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Few Stroke Patients Given Clot-Buster Quickly Enough: Study

Few eligible stroke patients get an injectable clot-busting drug within the recommended 60-minute window after their hospital arrival, new research finds. "It has been widely recommended that the 'door-to-needle' time should be 60 minutes," said study author Dr. Gregg C. Fonarow, a professor of cardiovascular medicine at the University of California Los Angeles David Geffen School of Medicine. The phrase refers to the timeframe between when the patient arrives at the hospital and when that patient is given the clot-buster, known as tissue plasminogen activator (tPA).

In his analysis of stroke patients from 1,083 hospitals, he found the 60-minute window was not the typical reality. "That occurs only in 26.6 percent of patients," he said. Fonarow was slated to present the findings Thursday at the American Stroke Association's International Stroke Conference in Los Angeles; the research is being published simultaneously in the journal Circulation. Perhaps even more surprising, the hospitals in the study were all participating in the American Heart Association/American Stroke Association's Get with The Guidelines-Stroke quality improvement program, which recommends early tPA administration.

"It involved some of the largest, best-known hospitals for stroke care," Fonarow said. The study looked at more than 25,500 patients who had suffered ischemic stroke in which a blood clot obstructs blood flow and had been treated with tPA within three hours of the start of symptoms. Just 6,790 got the intravenous drug within 60 minutes. During the course of the study, there was only modest improvement in the hospitals' track records.

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Lead Exposure May Raise Blood Pressure in Pregnancy

In pregnant women, even small amounts of lead in the blood may cause significantly higher blood pressure, new research suggests. The study of 285 pregnant women found that about one in four had a lead level higher than about 1 microgram per deciliter (1 mcg/dL) of umbilical cord blood. That's significantly lower than the safety thresholds set by the U.S Centers for Disease Control and Prevention, which recommends taking action to reduce lead exposure when pregnant women or children have a blood lead level of 5 mcg/dL.

Even so, women in the study with lead levels greater than 1 mcg/dL had higher systolic and diastolic blood pressure readings than those with lower lead levels. The average increase was 6.9 mm Hg and 4.4 mm Hg, respectively. Though further research is needed, the findings suggest that pregnant women may be as sensitive to lead toxicity as young children, said the researchers. Prolonged high blood pressure during pregnancy can lead to complications such as preeclampsia or eclampsia, potentially deadly seizures that also can increase a woman's future risk of heart attack.

"We didn't expect to see effects at such low levels of lead exposure, but in fact we found a strong effect," Dr. Lynn Goldman, dean of the George Washington University School of Public Health and Health Services, said in a university news release. The study did not find an association, however, between lead exposure and pregnancy-induced hypertension or preeclampsia.

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Docs Claim Transplant Cured Man of HIV, But Experts Urge Caution

In a rare case, a man living in Germany who had both leukemia and AIDS no longer has any detectable HIV cells in his blood following a stem cell transplant for his leukemia three years ago. But experts were quick to caution that the case does not have practical implications for the treatment of AIDS worldwide. As it turns out, the donor for that transplant carried a rare mutation in a gene that increases immunity against the most common form of HIV.

First reported in 2009, this follow-up study, published online in the journal Blood, confirms that the recipient patient is still free of both leukemia and HIV three years after the transplant. But one expert issued strong words of caution in interpreting the finding. "Our phones have been ringing off the hook," said Dr. Margaret Fischl, director of the AIDS clinical research unit at the University of Miami Miller School of Medicine. "We are having patients calling us and asking if they can stop their antiretroviral therapy and the answer is uncategorically no."

The theory is that if you could wipe out every infected cell you could cure HIV, Fischl said, but this is a unique case. The patient had intense chemotherapy and radiation, then relapsed and was given a second transplant from the same donor. The donor was unique in that he had a gene that could fight the most common form of HIV. This mutation is seen in about one in every million people, Fischl explained.

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Eating Peanuts While Pregnant May Raise Child's Allergy Risks

Women who eat peanuts during pregnancy may be putting their babies at increased risk for peanut allergy, a new study suggests. U.S. researchers looked at 503 infants, aged 3 months to 15 months, with suspected egg or milk allergies, or with the skin disorder eczema and positive allergy tests to milk or egg. These factors are associated with increased risk of peanut allergy, but none of the infants in the study had been diagnosed with peanut allergy. Blood tests revealed that 140 of the infants had strong sensitivity to peanuts. Mothers' consumption of peanuts during pregnancy was a strong predictor of peanut sensitivity in the infants, the researchers reported in the Nov. 1 issue of the Journal of Allergy and Clinical Immunology.

"Researchers in recent years have been uncertain about the role of peanut consumption during pregnancy on the risk of peanut allergy in infants. While our study does not definitively indicate that pregnant women should not eat peanut products during pregnancy, it highlights the need for further research in order to make recommendations about dietary restrictions," study leader Dr. Scott H. Sicherer, a professor of pediatrics at Jaffe Food Allergy Institute at the Mount Sinai School of Medicine in New York City, said in a journal news release. Sicherer and his colleagues recommended controlled, interventional studies to further explore their findings. "Peanut allergy is serious, usually persistent, potentially fatal, and appears to be increasing in prevalence," Sicherer said.

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Doctors Ordering Transfusions to Get Patients into Drug Trials

Canadian researchers say they've noticed a disturbing trend: Cancer doctors ordering unnecessary blood transfusions so that seriously ill patients can qualify for drug trials. In a letter published recently in the New England Journal of Medicine, the researchers report on three cases during the last year in Toronto hospitals in which physicians ordered blood transfusions that could make the patients appear healthier for the sole purpose of getting them into clinical trials for chemotherapy drugs. The practice raises both medical and ethical concerns, the authors say.

"On the physician side, you want to do the best for your patients," said co-author Dr. Jeannie Callum, director of transfusion medicine and tissue banks at Sunnybrook Health Sciences Centre in Toronto. "If these patients have no other options left to them, you want to do everything you can to get them into a clinical trial," she said. "But the patient is put in a horrible position, which is, 'If you want in to the trial, you have to have the transfusion.' But the transfusion only carries risks to them," she added.

A particularly serious complication of blood transfusions is transfusion-related acute lung injury, which occurs in about one in 5,000 transfusions and usually requires the patient to go on life support, said Callum. But besides the potential for physical harm, enrolling very sick people in a clinical trial can also skew the study's results making the drug perform worse than it might in patients whose disease was not as far along. The unnecessary transfusions were discovered by the Toronto Transfusion Collaboration, a consortium of six city hospitals formed to carefully review all transfusions as a means of improving patient safety, Callum said.

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New CPR Guidelines Emphasize Compressions First

Don't fret about mouth-to-mouth. The average, untrained person can still save a life by focusing on chest compressions first, say new guidelines from the American Heart Association. The simplified form of cardiopulmonary resuscitation, or CPR, focuses on giving chest compressions to keep the blood and the oxygen in the blood flowing to the heart and brain. The group's advice comes on the heels of studies in the past year trumpeting that a compression-only approach is as good or better than compression plus mouth-to-mouth. It updates guidelines from 2005.

"For a variety of reasons, when someone suddenly collapses in cardiac arrest, people often don't start any type of CPR, and one of the barriers, we believe, is that people think it's fairly complicated to do CPR," explained Dr. Michael Sayre, co-author of the new guidelines and chairman of the American Heart Association's emergency cardiovascular care committee. "But chest compressions alone are easy, and anyone can do it," he said. "Chest compressions actually act like an artificial heart, pumping blood to the heart and brain," Sayre noted. "And, that blood often will have a reserve of oxygen."

The American Heart Association recommends that if an adult is unresponsive and not breathing or is having occasional unusual breaths that sound like gasping, any bystander should first call 911 and then begin chest compressions. If someone else is nearby, send that person in search of an automatic external defibrillator, a device that can shock the heart back into normal rhythm. "To give the victim the best chance of survival, three actions must occur within the first moments of a cardiac arrest: activation of the EMS system, provision of CPR and operation of a defibrillator," the new guidelines state.

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High Blood Sugar Levels Increase Infection Risk From General Surgery

High blood sugar levels can increase the risk of surgical site infections in patients having general surgery, researchers report. Doctors have long been aware that people with diabetes are more prone to surgical infections, and the relationship between high blood sugar and increased risk of infection after surgery is well known in heart and intensive care unit surgery, where blood sugar is carefully monitored. But this appears to be the first study to quantify the risk after general surgery, noted the study authors, from Albany Medical College in New York.

"We wanted to find out how much increased glucose in your blood had a role in infection in general surgery," said lead researcher Ashar Ata, from the College's Department of Surgery. "Surprisingly, we did find that by the time your glucose is higher than 140 milligrams per deciliter, the infection went from 1.8 percent to almost 10 percent." When blood sugar levels reach that point, medical staff should intervene to control them, Ata said, adding, "We found the higher the blood glucose, starting at about 110 milligrams per deciliter, the more likely you are to have an infection."

The report is published in the September issue of the Archives of Surgery. The procedures Ata's group looked at included appendectomy, colon surgery, hemorrhoid removal and gallbladder removal, he said. These operations all fall under the definition of general surgery. For the study, Ata's team looked at medical records of 2,090 patients who had had general or vascular surgery between Nov. 1, 2006, and April 30, 2009. Among these patients, the researchers studied the blood sugar levels of 1,561 patients, including those who had vascular surgery, colorectal surgery and other types of general surgery.

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Recurring Stroke Risk Higher for Some Hispanics

Mexican-American stroke survivors with a heart rhythm disorder called atrial fibrillation are more than twice as likely to suffer a second stroke compared to white patients, a new study finds. It also found that even though these strokes are more likely to be severe among Mexican-Americans, they don't have a greater risk of death after a second stroke. In people with atrial fibrillation, the heart's upper chambers (atria) beat irregularly and don't pump blood effectively. This can cause blood to pool within the atria, which can lead to the formation of blood clots that can break off and travel to the brain, causing a stroke.

This study included 88 Mexican-Americans and 148 white stroke survivors with atrial fibrillation. Compared to the white patients, the Mexican-American stroke survivors were younger, less likely to have completed 12 years of education, more likely to have diabetes, and less likely to have a primary care physician. Over a median follow-up of 427.5 days, 19 Mexican-Americans and 14 whites had at least one recurrent stroke. All but one of those cases involved an ischemic stroke, which is caused by blocked blood flow to the brain. One Mexican-American patient suffered a hemorrhagic stroke, which is bleeding in the brain.

The study appears in the current issue of the journal Stroke. "Based on some of our prior research, we were not necessarily surprised by the higher recurrence rate in Mexican-Americans with atrial fibrillation, but the greater severity of recurrent strokes in Mexican-Americans was surprising," co-author Dr. Darin B. Zahuranec, an assistant professor of neurology at the University of Michigan Cardiovascular Research Center in Ann Arbor, said in an American Heart Association news release. One reason for the difference in stroke rates could be that Mexican-Americans may not have managed the blood-thinning drug warfarin often used to prevent stroke in the most optimal way, Zahuranec said. He and his colleagues did not evaluate outpatient use of warfarin, which might have contributed to the increased risk of stroke in Mexican-Americans.

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Chemicals in Rugs, Cookware May Be Linked to Raised Cholesterol in Teens

Common chemicals found in everything from non-stick cookware to grease-resistant food packaging appear to be associated with increases in cholesterol levels in adolescents, a new study suggests. People are exposed to these chemicals known as perfluoroalkyl acids (PFAAs)in dust, drinking water, non-stain carpets, waterproof fabrics, microwave popcorn bags and a host of other household products. "This is the first study that takes an in-depth look at an association between these chemicals and health effects in children," said study author Stephanie J. Frisbee, research instructor in the Department of Community Medicine at West Virginia University School of Medicine in Morgantown.

The PFAA compounds in question include perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS). "We found a positive association between PFOA and PFOS and total [cholesterol] and LDL cholesterol," she said. As the blood levels of these chemical increased, so did cholesterol, Frisbee added. The American Chemical Council, an industry group, did not respond to repeated attempts by HealthDay to get comment on the findings. The report is published in the September issue of the Archives of Pediatrics & Adolescent Medicine. For the study, Frisbee's team looked at cholesterol levels in more than 12,000 children and adolescents who are part of the C8 Health Project.

This project resulted from the settlement of a class-action lawsuit against Dupont over the landfill dumping of chemicals that contaminated groundwater in six water districts in two states near the company's plant in Parkersburg, West Virginia, and exposed residents to levels of C8 (another name for PFOA) far higher than that of the general population. Among the participants, the average PFOA concentration was 69.2 nanograms per milliliter and average PFOS concentration was 22.7 nanograms per milliliter. Among 12- to 19-year-olds, the PFOA concentrations were higher than those seen in the general population, but PFOS concentrations were similar to those seen in samples from the general population, the researchers found.

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Diabetes Drug Metformin Linked to Lower Lung Cancer Rate in Mice

A drug widely used to treat high blood sugar in type 2 diabetics may hold some promise in the prevention of tobacco-induced lung cancer, according to extremely preliminary findings in a mouse study. In the September issue of Cancer Prevention Research, researchers report that metformin was associated with a substantial reduction (up to 73 percent) in the number of tumors mice developed when they were given a common carcinogen found in tobacco. Despite the fact that there have been no randomized controlled trials on whether metformin really can prevent cancer, researchers expressed excitement both over this animal study and previous epidemiological evidence pointing to this possibility.

Metformin has been in use for more than two decades and is currently prescribed to 40 million Americans. "This is a very safe agent and has been around for a while," said Cancer Prevention Research editor-in-chief Dr. Scott Lippman, chair of thoracic head and neck medical oncology at the University of Texas M.D. Anderson Cancer Center in Houston, at a Wednesday news conference. "The evidence in diabetic humans is very convincing and very strong," added Dr. Phillip Dennis, a senior investigator with the U.S. National Cancer Institute and senior author on the lung cancer paper. "Almost every epidemiological study I can think of found a decreased cancer incidence in diabetics taking metformin. The reduction is real and ranges from 30 to 70 percent."

The researchers thought metformin's possible cancer-lowering properties suggested the need for clinical trials to investigate whether the drug might help prevent tumors in smokers at high risk of developing cancer. Others believed that the finding might influence the choice of drugs in people with diabetes. "All other things being equal, many diabetics face a choice of oral agents, and early evidence that metformin may have an effect on the oncology side may increasingly play a role in decision-making," said Dr. Michael Pollack, professor of medicine and oncology at McGill University in Montreal. "We can't ignore this, but we can't say we have FDA approval for metformin for cancer indications."

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Clues to Heart Attack, Stroke Risk From Fat-Filled Artery

A number of factors put patients with abnormal fatty deposits in an artery at high risk for heart attack, stroke and cardiovascular death, a new study shows. Patients in various stages of this condition atherothrombosis are at increased risk for heart attack and stroke stemming from reduced blood flow from the artery blockage, but some are at greater risk than others. In an analysis of more than 45,000 patients, the researchers found that patients with abnormal fatty deposits in an artery were at highest risk if they had a prior history of heart attack or other emergencies linked to an artery blockage.

Narrowing of the arteries in various locations also substantially increased the risk for patients with atherothrombosis, as did diabetes for all the patients even those with only the risk factors for atherothrombosis.Knowing that these factors boost the risk can help physicians take preventive action, according to the researchers, who are from the VA Boston Healthcare System, Brigham and Women's Hospital and Harvard Medical School in Boston. The researchers analyzed data from 45,227 patients enrolled in an international study known as Reduction of Atherothrombosis for Continued Health (REACH) between 2003 and 2004. They collected detailed information from the patients when they enrolled and conducted follow-ups one, two, three and four years later.

They found that 81.3 percent of the patients had hypertension, 70.4 percent had high  cholesterol levels in the blood, and 15.9 percent had polyvascular disease . In addition, 48.4 percent of the patients had "ischemic events" prior heart attacks, unstable angina or other problems related to the artery blockage, with 28.1 percent of those patients having had such an event within the previous year. During the follow-up period, 2,315 patients suffered cardiovascular death, 1,228 had a heart attack, 1,898 had a stroke, and 40 had a heart attack and a stroke on the same day. The researchers found that patients with atherothrombosis with a prior history of heart attacks and other events related to a blood vessel blockage had the highest rate of subsequent cardiac emergencies linked to blood flow problems.

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Quality of Care After Joint Surgery May Affect Heart Health

The quality of care a patient receives immediately after orthopedic surgery has a major impact on long-term heart health, a new study shows. A team of French researchers checked troponin levels in 378 patients for three days after they had orthopedic surgery, which includes procedures such as joint replacement. Troponin is a protein that's measured to determine whether physiologic stress related to surgery has caused damage to the heart. Dr. Sylvain Ausset, of Percy Military Hospital in Clamart, France, and colleagues focused on troponin levels to detect myocardial ischemia, which correlated with worse long-term cardiac outcomes.

The researchers then modified postoperative care to reduce events believed to lead to increased episodes of angina based on elevated troponin levels. Doing so lowered the incidence of cardiac problems months, and even years, later, they found.The methods used to improve quality of care included tighter control of oxygen and glucose levels in patients' blood, along with consistency and continuity of care as hospital staff monitored and cared for patients, according to the report published in the October issue of Anesthesiology.

"An improvement of quality of postoperative care results in a twofold decrease of postoperative myocardial ischemia and a fourfold decrease of major cardiac events later on," Ausset said in a news release from the American Society of Anesthesiologists. The findings could lead to new or improved clinical guidelines, according to an accompanying editorial written by Dr. Don Poldermans, of Erasmus Medical Center in Rotterdam, the Netherlands.

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Slowed Reflexes in Aging Could Be Due to Brain Changes

Breakdowns in brain connections may be the reason why your physical response times slow as you age, a new study has found. The decline occurs in an area of the brain called the corpus callosum, which helps regulate "cross-talk" between the two sides of the brain, said lead author Rachael Seidler, an associate professor in the School of Kinesiology and psychology department at the University of Michigan. Normally, one side of the brain controls movement on the opposite side of the body. For example, the left side of the brain controls movement on the right side of the body.

But when regulation of cross-talk between the two sides of the brain starts to break down with age, both sides of the brain talk simultaneously while one side of the body tries to move, resulting in slower response times, the researchers explained. Seidler and colleagues studied the response times and brain activity of adults aged 65 to 75 as they used computer joysticks, and compared them to a group of 20-25 year olds. They also used a functional MRI to image the blood oxygen levels in different parts of the brain, as a measurement of brain activity in the older group. "The more they recruited the other side of the brain, the slower they responded," Seidler said in a University of Michigan news release.

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Generics As Good As Costly Blood Pressure Meds, Study Finds

Costly, brand-name blood pressure-lowering drugs are no better at preventing cardiovascular disease than older, generic diuretics, reveals long-term data from a large study. It included more than 33,000 patients with high blood pressure who were randomly selected to take either a diuretic or one of two newer drugs a calcium blocker or an ACE inhibitor. Data from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial released in 2002 showed that after four to eight years of follow-up, the diuretic was better than the calcium blocker in preventing heart failure and better than the ACE inhibitor in preventing stroke, heart failure and overall cardiovascular disease.

Differences between the drugs narrowed after eight to 13 years of follow-up, the findings show. However, the diuretic was still better in two areas. Compared with patients taking the diuretic, those in the ACE inhibitor group had a 20 percent higher death rate from stroke, and those in the calcium channel blocker group had a 12 percent higher rate of hospitalization and death because of heart failure. The results were to be presented Friday at the China Heart Congress and International Heart Forum in Beijing. "We are continuing to mine data that we collected during the trial," Dr. Paul Whelton, president and CEO of Loyola University Health System and chairman of ALLHAT, said in a university news release. ALLHAT is sponsored by the U.S. National Heart, Lung and Blood Institute.

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